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matrix gla protein  (BEHRINGER International GmbH)

 
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    BEHRINGER International GmbH matrix gla protein
    Matrix Gla Protein, supplied by BEHRINGER International GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/matrix+gla+protein/matrix+gla+protein/pm39453431-522-25-10
    Average 90 stars, based on 1 article reviews
    matrix gla protein - by Bioz Stars, 2026-11
    90/100 stars

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    Article Title: Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin K
    Article Snippet: The European Food Safety Authority (EFSA) carried out a public consultation to receive input from the scientific community and all interested parties on the draft Scientific Opinion on Dietary Reference Values (DRVs) for vitamin K, prepared by the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) and endorsed by the Panel for public consultation at its Plenary meeting on 25 October 2016.. The written public consultation for this document was open from 13 January to 24 February 2017.. EFSA received comments from 10 interested parties.

    Article Title: Transporters for the Intestinal Absorption of Cholesterol, Vitamin E, and Vitamin K
    Article Snippet: Curr Opin Lipidol, 2014; 25: 200-206 75) Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR and Karsenty G: Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.

    Article Title: Vitamin K deficiency: an emerging player in the pathogenesis of vascular calcification and an iatrogenic consequence of therapies in advanced renal disease.
    Article Snippet: 33 Vascular calcification is a known complication of chronic kidney disease (CKD).. The 34 prevalence of vascular calcification in patients with non-dialysis-dependent CKD stages 35 3-5 has been shown to be as high as 79%. (20) Vascular calcification has been 36 associated with increased risk for mortality, hospital admissions, and cardiovascular 37 disease. (20) (55) (6) (50) Alterations in mineral and bone metabolism play a pivotal role 38 in the pathogenesis of vascular calcification in CKD.. As CKD progresses, levels of 39 fibroblast growth factor-23 (FGF-23), parathyroid hormone (PTH) and serum 40 phosphorus increase and 1,25-(OH)2 vitamin D decreases.

    Article Title: New perspectives on rare connective tissue calcifying diseases.
    Article Snippet: Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G: Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.

    Article Title: Femoral Neck X-Ray Absorptiometry Parameters and Peripheral Quantitative Computer Tomography Tibial Cortical Density Predict Survival in Dialysis Patients.
    Article Snippet: Background: Low bone mineral density (BMD) is a known independent predictor of mortality in the general elderly population.. However, studies in patients with end-stage renal disease (ESRD) are limited.. The present study evaluated mortality during long-term follow-up in a population of patients having dialysis for ESRD, in whom BMD was also measured.

    Article Title: Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP.
    Article Snippet: Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.

    Article Title: Metabolites and Metabolism in Vascular Calcification: Links Between Adenosine Signaling and the Methionine Cycle.
    Article Snippet: Metabolites and Metabolism in Vascular Calcification: Links Between Adenosine 1 Signaling and the Methionine Cycle 2 3 Parya Behzadi and Cynthia St. Hilaire 4 5 Department of Medicine, Division of Cardiology, and the Pittsburgh Heart, Lung, and Blood 6 Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA 7 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA 8 9 Address for Correspondence: 10 Cynthia St. Hilaire, PhD, FAHA 11 BSTWR 1744 12 200 Lothrop Street 13 Pittsburgh, PA, USA 15260 14 +1 412-648-9441 15 sthilair@pitt.edu 16 17 Running Head: Adenosine & Methionine Pathways in Vascular Calcification 18 19

    Article Title: Direct Observation of Spiral Growth, Particle Attachment, and Morphology Evolution of Hydroxyapatite
    Article Snippet: The two main pathways for the growth of calcium phosphates are either via the addition of monomeric chemical species to existing steps or via the attachment of precursor particles.. Although recent experimental evidence suggests that the particle-attachment pathway is prevalent, real-time observations for the relative contributions of monomer-by-monomer addition or attachment of particles to seed crystals remain limited.. Here we present an in situ study of hydroxyapatite (HAP) (100) surface growth with long imaging times by atomic force microscopy (AFM).



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    ( A ) Schematic illustration of the experimental procedure of proteomic analysis. ( B ) Classification of interface-enriched proteins based on functions described in Genecards Database. ( C ) Volcano plots of protein expression differences between interface and bone, and interface and root. Proteins with statistically significant differences in expression were colored in orange (significantly higher in interface) and blue (significantly lower in interface) ( p adjusted value < 0.05, fold change > 2). ( D ) Immunofluorescent staining of <t>MGP</t> at the S-H interface. ( E ) MGP protein expression profile across the S-H interface quantified using fluorescent signal intensity which increased in the mineralized tissue region and S-H interface (denoted by dashed line). ( F ) Functional verification of MGP’s role as a mineralization inhibitor through in vitro mineralization using nano-ACP. TEM images showed the increase in HAP crystals in the non-treated group was less than in the MGP-treated group on day 1 and day 3. Inlets revealed diffraction patterns of associated areas. ( G ) Quantification of HAP crystal density in TEM snapshots (n=5) of MGP-treated and non-treated groups. Statistical significance is illustrated as: *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001. Abbreviations: LC-MS/MS, liquid chromatography−tandem mass spectrometry; MGP, matrix Gla protein.
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    ( A ) Schematic illustration of the experimental procedure of proteomic analysis. ( B ) Classification of interface-enriched proteins based on functions described in Genecards Database. ( C ) Volcano plots of protein expression differences between interface and bone, and interface and root. Proteins with statistically significant differences in expression were colored in orange (significantly higher in interface) and blue (significantly lower in interface) ( p adjusted value < 0.05, fold change > 2). ( D ) Immunofluorescent staining of MGP at the S-H interface. ( E ) MGP protein expression profile across the S-H interface quantified using fluorescent signal intensity which increased in the mineralized tissue region and S-H interface (denoted by dashed line). ( F ) Functional verification of MGP’s role as a mineralization inhibitor through in vitro mineralization using nano-ACP. TEM images showed the increase in HAP crystals in the non-treated group was less than in the MGP-treated group on day 1 and day 3. Inlets revealed diffraction patterns of associated areas. ( G ) Quantification of HAP crystal density in TEM snapshots (n=5) of MGP-treated and non-treated groups. Statistical significance is illustrated as: *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001. Abbreviations: LC-MS/MS, liquid chromatography−tandem mass spectrometry; MGP, matrix Gla protein.

    Journal: bioRxiv

    Article Title: A Tough Biointerface in Human Knee Empowered by Dynamic Phase-transforming Minerals in Collagenous Matrix

    doi: 10.1101/2024.08.03.606023

    Figure Lengend Snippet: ( A ) Schematic illustration of the experimental procedure of proteomic analysis. ( B ) Classification of interface-enriched proteins based on functions described in Genecards Database. ( C ) Volcano plots of protein expression differences between interface and bone, and interface and root. Proteins with statistically significant differences in expression were colored in orange (significantly higher in interface) and blue (significantly lower in interface) ( p adjusted value < 0.05, fold change > 2). ( D ) Immunofluorescent staining of MGP at the S-H interface. ( E ) MGP protein expression profile across the S-H interface quantified using fluorescent signal intensity which increased in the mineralized tissue region and S-H interface (denoted by dashed line). ( F ) Functional verification of MGP’s role as a mineralization inhibitor through in vitro mineralization using nano-ACP. TEM images showed the increase in HAP crystals in the non-treated group was less than in the MGP-treated group on day 1 and day 3. Inlets revealed diffraction patterns of associated areas. ( G ) Quantification of HAP crystal density in TEM snapshots (n=5) of MGP-treated and non-treated groups. Statistical significance is illustrated as: *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001. Abbreviations: LC-MS/MS, liquid chromatography−tandem mass spectrometry; MGP, matrix Gla protein.

    Article Snippet: 200-mesh golden grids with a carbon support film were added with 3 μL recombinant matrix gla protein (MGP) (100 μg/mL, CUSABIO, China) diluted with deionized water and the control group was added with 3 μL deionized water, and both were incubated for 20 minutes at room temperature.

    Techniques: Expressing, Staining, Functional Assay, In Vitro, Liquid Chromatography with Mass Spectroscopy, Liquid Chromatography, Mass Spectrometry

    The left panel illustrates the hierarchical structure of the meniscus root-bone interface under static condition. From macroscale to nanoscale: histological zones of the root-bone interface; transformation of mineral aggregates from ACP, immature HAP to HAP alongside mineralization of collagen fibrils; ACP, immature HAP and collagen form molecular bonds with collagen fibrils, while MGP protein and proteoglycans interact with the mineral aggregates and collagen to mediate mineralization. The right panel demonstrates the multiscale mechanical response upon mechanical loading. From macroscale to nanoscale: soft tissue responds to stress first via fiber stretching and straightening while the interface responds last, and cracks would be deflected or blunted; the ACP and immature aggregates dissipate stress (denoted by “E”) through sliding in the interfibrillar space, and crack would be arrested by stiff mineral aggregates; bonds among mineral aggregates and collagen could break for energy dissipation, and new bonds formation could occur simultaneously. Abbreviations: LR, ligamentous root; FC, fibrocartilage; MFC; mineralized fibrocartilage; ACP, amorphous calcium phosphate; HAP, hydroxyapatite; MGP, matrix gla protein.

    Journal: bioRxiv

    Article Title: A Tough Biointerface in Human Knee Empowered by Dynamic Phase-transforming Minerals in Collagenous Matrix

    doi: 10.1101/2024.08.03.606023

    Figure Lengend Snippet: The left panel illustrates the hierarchical structure of the meniscus root-bone interface under static condition. From macroscale to nanoscale: histological zones of the root-bone interface; transformation of mineral aggregates from ACP, immature HAP to HAP alongside mineralization of collagen fibrils; ACP, immature HAP and collagen form molecular bonds with collagen fibrils, while MGP protein and proteoglycans interact with the mineral aggregates and collagen to mediate mineralization. The right panel demonstrates the multiscale mechanical response upon mechanical loading. From macroscale to nanoscale: soft tissue responds to stress first via fiber stretching and straightening while the interface responds last, and cracks would be deflected or blunted; the ACP and immature aggregates dissipate stress (denoted by “E”) through sliding in the interfibrillar space, and crack would be arrested by stiff mineral aggregates; bonds among mineral aggregates and collagen could break for energy dissipation, and new bonds formation could occur simultaneously. Abbreviations: LR, ligamentous root; FC, fibrocartilage; MFC; mineralized fibrocartilage; ACP, amorphous calcium phosphate; HAP, hydroxyapatite; MGP, matrix gla protein.

    Article Snippet: 200-mesh golden grids with a carbon support film were added with 3 μL recombinant matrix gla protein (MGP) (100 μg/mL, CUSABIO, China) diluted with deionized water and the control group was added with 3 μL deionized water, and both were incubated for 20 minutes at room temperature.

    Techniques: Transformation Assay